Just don't tell these guys that they are supposed to be fighting like cats and dogs
But, seeing as they were friends since being two weeks old, these litters of wolves and tigers share a unique bond.
Separated from their mothers to insure their survival, they are beginning their journey as animal ambassadors at The Institute of Greatly Endangered and Rare Species - conveniently abbreviated to 'Tigers'.
The young timber wolves and Bengal tigers seem unaware that they are supposed to be sworn enemies as they play for the cameras in their South Carolina home.
Now aged three months, and sharing the same bottles of milk formula, the 25lb wolf cubs are twice the weight of their tiger bedfellows.
The founder of Tigers, Doc Bhagavan, said: 'At the moment the tigers will have a size and weight disadvantage to their canine friends.
'So that means that the wolves are a bit pushy with their tiger pals in their shared environment.'
After one year the tiger cubs will be expected to weigh around 250lb compared to the year-old wolves at 180lb.
Mr Bhagavan said: 'Even though they will have spent eight months together, after that time they will have to be separated.
The size difference and species difference will become apparent.'